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The chloroplastic isoform is likely required for the de novo methionine synthesis whereas cytosolic isoforms are most probably involved in the regeneration of Met from homocysteine (Ravanel et al., 2004)

From a systems perspective, anxiety disorders is characterized by abnormalities in neurotransmitter functions, neurotrophic signaling, the endocannabinoid system and HPA axis function and these alterations are further compounded by chronic inflammation and maladaptive immune responses (Cai et al., 2025)

Relationship between serum B 12 concentrations and mortality: experience in NHANES

FIGURE 10 Oxidative stress, associated with high dose MTX, triggers a systemic inflammatory response where proinflammatory cytokines further contribute to tissue damage (Kalantar et al., 2019a