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Par principe de prcaution, aprs avoir examin diffrentes tudes et pris en compte de nombreux facteurs, parmi lesquels la variabilit de l'absorption, les pertes quotidiennes et la rduction du taux d'absorption des apports levs

Doses of pyridoxine as low as 5-10 mg can antagonize levodopas effect if carbidopa is not present, so caution is warranted and any supplemental B beyond the nutritional dose should be under medical guidance

Its efficacy and tolerability is currently being evaluated in a phase 3 trial [77] (Table 2 )

Once the root cause is identified, the appropriate form of supplementation (oral, sublingual or injection), dosages and length of intervention can be determined, as well as any gut healing and rebalancing that needs to occur to heal the root cause/s