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Many people live with low or borderline vitamin levels that impact energy, brain function, immunity, and overall resilience, often without obvious symptoms

10.1158/2159-8290.CD-20-1265 Cancer Discov

Humans and other eukaryotic organisms lack the enzymatic machinery necessary for de novo Cbl synthesis and rely on external sources, such as diet or symbiotic bacteria, to obtain Cbl [85, 86]

This amino acid is also used as the main oxidative fuel to replenish intermediates of the tricarboxylic acid cycle in rapidly dividing cells [1], such as enterocytes and colonocytes [6], fibroblasts, and immune cells such as lymphocytes [7, 8], macrophages, and neutrophils [9,10,11,12]