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Calpain-2 activation might exacerbate tau pathology as TBI mouse models have revealed calpain-2 activation resulted in increased tyrosine phosphorylation of kinase c-Abl at Tyr245, resulting in increased kinase activity and phosphorylation of tau at Tyr394 (Wang et al., 2017)

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Role for substance Pbased nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects