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When Nrf2 is released from Kelch-like ECH-associated protein 1 (Keap1) and translocates to the nucleus, Nrf2 binds to antioxidant-responsive elements (AREs) in the promoter/enhancer region of phase II detoxification and antioxidant enzyme genes with the Maf (Musculoaponeurotic fibrosarcoma) protein [58,59]

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Research points to several interacting drivers: Estrogen and Progesterone Signalling Fibroids are hormone-sensitive growths
