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A landmark 2014 PET scan study published in The Journal of Nuclear Medicine demonstrated that neuroinflammation driven by activated microglia was up to 199% higher in ME/CFS patients compared to healthy controls

METH can cause a dramatic increase and release of serotonin in the body, which is due to its indirect effect on the 5-HT transporter (SERT) (Sora et al., 2009)

13 The ECS is made up of multiple components: (a) signaling molecules called endocannabinoids, (b) specific receptors, and (c) enzymes that synthesize and breakdown endocannabinoids and transporters of endocannabinoids
