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[DOI] [PubMed] [Google Scholar] Kishino S

Health consequences of iodine deficiency

Xue et al., 2022)
In Atg7-deficient mice, the loss of autophagy in hematopoietic stem cells not only leads to increased aberrant myeloid expansion, resulting in severe myeloid dysplasia and infiltrating myeloid blast cells evoking AML [18] but can also activate the NOTCH signaling pathway, blocking HSC differentiation and leading to a leukemic phenotype [19]
