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More alarming, vitamin B12 deficiency was twice as common among those taking metformin
Its use in humans outside an FDA-authorized clinical trial is illegal

All of our regimens will provide a physiologically negligible amount of cyanide well below the EFSAs acute reference dose safety threshold of 20 g/kg of body weight (1,270 g for a 140 lb (63.5 kg) person) per day

ISBN 0-13-961905-4.