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This initiates a cascade of intracellular signaling reactions leading to molecular, cellular, and interstitial alterations, which manifest clinically as changes in the size, shape, and function of the heart

From 205 in clinic

10.1016/j.molcel.2022.03.022 [DOI] [PMC free article] [PubMed] [Google Scholar] 42

The simultaneous presence of both these cytokines has a detrimental effect on intestinal integrity through the disassociation of tight junction proteins 63,64
