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This initiates a cascade of intracellular signaling reactions leading to molecular, cellular, and interstitial alterations, which manifest clinically as changes in the size, shape, and function of the heart

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From 205 in clinic

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10.1016/j.molcel.2022.03.022 [DOI] [PMC free article] [PubMed] [Google Scholar] 42

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The simultaneous presence of both these cytokines has a detrimental effect on intestinal integrity through the disassociation of tight junction proteins 63,64

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