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Abstract Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and disturbances in GSH homeostasis are involved in the etiology and progression of many human diseases including cancer

rather, it is synthesized in extragonadal sites such as breast, brain, muscle, bone, and adipose tissue where it acts locally as a paracrine or intracrine factor (8)

Mechanism of oxidative stress in IBD While the precise mechanisms responsible for the development of IBD remain unclear, it is widely accepted that multiple factors contribute to its etiology, including overproduction of ROS, damage to biomolecules, mitochondrial dysfunction, recruitment of immune cells, impaired antioxidant defense system, and the activation of inflammatory pathways ( Figure 1 )
10.1210/er.2002-0005 28 De MillianoI.Van HattumD.KetJ
