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Mechanistically, GTP hydrolysis is known to induce a conformational switch in the G2 loop and Cys -Pro- His Ni II -binding motif in UreG (Figure 38A), 822 and perhaps only as part of the activation complex, may weaken the Ni II affinity and allow for dissociation of Ni II into the vestibule (Figure 34, bottom )

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Understanding the anagen phase connection Hair growth follows a cycle with three main phases