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Structural design Design delivery systems with specific structures and morphologies, such as multilayer nanoparticles or core-shell structured microspheres, to achieve pulsed or targeted drug release

Unlike the canonical ferroptosis pathway due to GPX4 inactivation, intracellular Fe 2+ accumulation, which can react with peroxides in the Fenton reaction, generates excess hydroxyl radicals, induces lipid peroxidation, and drives cellular ferroptosis [117, 118]

Ephedrine-like prescription and over-the-counter products should also generally be avoided in these patients

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