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Various physiological and pathological states, such as wound healing, tumor growth or regeneration after damage can be connected with this processes

Fatigue in patients with chronic disease: results from the population-based Lifelines Cohort Study
The periplasmic heme-binding protein and the inner membrane heme transporter have not yet been identified, while within the cytoplasm, heme is degraded by heme oxygenase (HemO), resulting in the release of iron (Zhu et al., 2000)

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