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In the Neelakantan study, diet-induced obese (DIO) C57BL/6 mice were treated with NNMT inhibitors including 5-Amino-1MQ analogues
Whilst mTORC1 activates S6 kinase, which phosphorylates serine residues on IRS which in turn uncouples IRS from the receptor and its substrates, mTORC2 can reactivate this signalling
Mood Enhancement: Low B12 levels are linked to mood disorders, including depression and anxiety
