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The data indicates that there is no amount of alcohol consumption that can be considered safe, and it is currently advised that MASLD patients should abstain from alcohol entirely 63

Cuprizone-induced demyelination in mouse brain is not due to depletion of copper

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance
[DOI] [PubMed] [Google Scholar] 208.Zambelli V.O., Fernandes A.C., Gutierrez V.P., Ferreira J.C., Parada C.A., Mochly-Rosen D., Cury Y