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It is important to understand that the conversions to active B 12 forms do not employ the methyl or adenosyl ligand from supplemental MeCbl or AdCbl, respectively

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Demyelination can impair neurological function, contributing to symptoms of mental fatigue, difficulty concentrating, and a general sense of being mentally 'foggy'all of which compound the physical tiredness

Methionine is one of the sulfur-containing amino acids (cysteine & cystine are others) and is important for many bodily functions