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Diet Preclinical and clinical studies over the past decade have suggested the ketogenic diet to be neuroprotective against AD by reducing A toxicity, decreasing neuroinflammation, protecting against reactive oxygen, and regulating mitochondrial homeostasis [256, 257]

and 25 patients received a combination of acetyl-l-carnitine at a dose used in arm A plus low-dose, i.e., 150 mg/day, pregabalin (arm C) for 8 weeks and were subsequently observed for an additional 8 weeks to assess relapse latency and frequency

Secondary endpoints, such as sural nerve conduction velocity and the Karnofsky physical score showed also a significant improvement in patients treated with ALC, compared to the placebo group

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