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Description
The pharmacokinetic effects of statins are unique, intestinal SLCO2B1 protein mediates the absorption of statins, which, through the intestinal CYP3A4 enzyme, are converted to active and inactive metabolites
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PMID 18272931.
This metabolic reprogramming is a new metabolic strategy adopted by tumor cells in response to changing microenvironmental and various stress conditions, aiming at supporting their proliferation, survival and invasiveness, thereby promoting tumor progression
