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Phosphorylated energy substrates with high-energy phosphate bonds such as phosphoenolpyruvate (PEP), 150,151 creatine phosphate, 26,152,153 or acetyl phosphate 154 were traditionally used as CFE substrates in combination with their respective kinases to generate ATP

doi: 10.1164/rccm.201708-1555OC 12 IsastiGMorenoTPerezICabreraFPalaciosRSantosJ

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The heavy use of kava appeared to be related to malnutrition and weight loss, liver damage (causing elevated serum -glutamyl transferase and high-density lipoprotein cholesterol levels), renal dysfunction, rashes, pulmonary hypertension, macrocytosis of red cells, lymphocytopenia, and decreasing platelet volumes