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Clinical trials with drugs that are already actively used in the clinic have several advantages, because drug repurposing can undergo a fast track regarding regulations [265]

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ADH1C shows two major functional variants, ADH1C*1 (rs1693482) and ADH1C*2 (rs698), that encode for isoforms that differ in in vitro activity, with the ADH1C*1 showing 1.5- to 2-fold greater activity than ADH1C*2 (113)

In addition to protecting damaged neurons, NAD+ precursors have shown promise in delaying the effects of several neurodegenerative diseases making this a must have treatment