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211 STOPMD-3, a late-stage clinical trial investigating the efficacy of ebselen in the treatment of hearing loss and tinnitus in Mnire disease, is in progress as of May 2023

Supportive care remains the cornerstone of therapy In early stage of this acute disease patient should be admitted to hospital for observation because the ascending paralysis may rapidly involve respiratory muscles Patients with slow progression may simply be observed for stabilization and spontaneous remission without treatment Rapidly progressive ascending paralysis is treated with intravenous immunoglobulin IVIG Each day counts after 1st motor symptom till 2 weeks, when treatment may be effectiveEither IvIg or Plasmapharesis, IvIg choosen for ease of administration & good saftey record GBS autoantibodies are neutralized by anti-idiotypic antibodies present in IVIg preparations Lack of noticeable improvement following IVIg or PE is not an indication to treat with the alternate one.In worsening case critical care monitoring for vital capacity, heart rhythm, blood pressure, nutrition, deep vein thrombosis prophylaxis, early consideration (after 2 weeks of intubation) for tracheostomy, and chest physiotherapySome may need temporary venous pacemaker Frequent turning, assiduous skin care, physiotherapy for joint contracture

J Biol Chem, 1999

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