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Timeline expectations: 48-72 hours (increased energy and reduced appetite), 1-2 weeks (initial weight loss 2-4 pounds), 4 weeks (noticeable body composition improvements), and 6 weeks (sustained metabolic enhancement and continued fat loss)

10.1002/dta.3225 [DOI] [PubMed] [Google Scholar] Piatkowski T., Puljevic C., Francis C., Ferris J., Dunn M
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[8] One purported mechanism of action is to induce acute local pain to compete directly with diffuse back pain through a mechanism called diffuse noxious inhibitory control
