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The larger pocket size of AtHTL might be the reason why AtHTL exhibited a slightly weaker affinity to KAR 1 than ShHTL1 and was able to hydrolyze rac -GR24 to some extent 26,34 and hydrolyze the synthesized desmethyl-YLG (dYLG), which is a smaller version of YLG 27

Biochimica et Biophysica Acta (BBA)Proteins Proteom 1854:166177 Skopelitou K, Muleta AW, Papageorgiou AC, Chronopoulou EG, Pavli O, Flemetakis E, Skaracis GN, Labrou NE (2017) Characterization and functional analysis of a recombinant tau class glutathione transferase GmGSTU2-2 from Glycine max

doi: 10.1038/s41590-019-0444-8 104 ZhangYBaileyJTXuESinghKLavaertMLinkVMet al

GorriniCHarrisISMakTW.Modulation of oxidative stress as an anticancer strategy