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Over the past two decades, extensive research has examined NACs actions within the CNS

Glutamate uptake by oligodendrocytes is the primary mechanism of glutamate clearance in white matter structures, and dysfunction of this transport system has been implicated in several diseases (SurezPozos et al

If ETC function is impaired, the TCA cycle can continue to generate metabolites by reductive mechanisms, including using pyruvate carboxylase to generate oxaloacetate from pyruvate for aspartate production, and glutamine-dependent reductive carboxylation for citrate synthesis (22, 23)

Glutathione is a master antioxidant produced by the body itself and present in almost every cell inside it