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After injection, you can rub the B12 injection site in a circular motion, which will increase blood flow and ease any irritation
Some people also have a hard time absorbing vitamin B12 through digestion
Blood Cancer J 11(2):17, 2021

But there are currently no provisions in the law for the FDA to approve dietary supplements for safety before they reach the consumer. The only scenario when a supplement manufacturer must submit safety information to the FDA before selling its product is when said product contains a new dietary ingredient.30 (A new dietary ingredient is one not sold in the U.S