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NF-B, nuclear factor B

The major ones: DNA methylation (turning genes on and off fundamental to how your cells regulate themselves), COMT (catechol-O-methyltransferase the enzyme that clears estrogen metabolites and stress neurotransmitters like adrenaline and noradrenaline), neurotransmitter metabolism (serotonin, dopamine, melatonin all require methylation steps in their synthesis or breakdown), creatine synthesis (which uses more SAMe than any other single reaction roughly 40% of all methyl groups go to creatine), and phospholipid production for cell membranes [1, 2]

In some instances, the cortisone shot might not work at all

What Causes SIBO