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Nevertheless, inactivation of LOXs induced by copper metabolic disorder or gene mutation would lead to dysfunction of connective tissues and collagen-containing organs (Kuivaniemi et al., 1982

Environ Microbiol 9:11011111 Lukatela G, Krauss N, Theis K, Selmer T, Gieselmann V, von Figura K, Saenger W (1998) Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis

However, while adults receiving vitamin E improved significantly transaminases, fibrosis, and NAS both at early and late follow-up, children showed more significant changes at long-term follow-up, which could partly explain the negative results obtained by certain short-term studies (128)