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Metformin has been associated with reduced vitamin B12 absorption through effects on calcium-dependent membrane action in the terminal ileum, which may be relevant for patients on chronic metformin therapy

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Reduced expression of mutant SOD1 in microglia delayed late disease progression and increased survival of SOD1 G37R mice (Boille et al., High calorie diets in ALS A number of studies have tried to correct the energy deficit using metabolic therapies in animal models and patients with ALS, with the hope that an improved metabolism can delay symptoms and extend survival in ALS (Dupuis et al., 2004