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2 Treadmill capacity in aged mice (Nature Communications, 2021) ~12 Rise in skeletal-muscle MOTS-c after exercise (humans) AMPK The exercise & fasting pathway it switches on 2015 Year MOTS-c was first characterized (Cell Metabolism) Studies show significant improvement in insulin sensitivity Research demonstrates AMPK pathway activation similar to exercise Trials showing reduced age-related metabolic dysfunction Emerging data on longevity and healthspan extension What to expect Your MOTS-C timeline

However, over time these levels go far down and, as a consequence, cells produce less energy and less metabolic activity

Sci World J 2013:565813

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