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It is evident from a growing number of studies that high-fat diets, drugs (antibiotics), and toxicants induce dysbiosis and improve the survivability of normally uncommon gut microbial species, leading to enhanced functional responses, pathogen infiltration, and further deterioration of gut health (Vascellari et al., 2021)

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The initial identification of ifenprodil as a NAM selective for NMDARs containing a GluN2B subunit triggered a rapid expansion of this pharmacological class that continues today [147,148,149,150]
