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As a group SARS-CoV viruses produce accessory proteins called open reading frames (ORF) which interact with mitochondrial outer membrane receptors
Liver slices from mice exhibited marked liver injury when incubated with acetaminophen, which was accompanied by extensive metabolism of the drug and by glutathione conjugate formation (demonstrating that metabolic bioactivation had occurred), while mouse liver slices that were incubated with equivalent doses of AMAP exhibited a markedly reduced extent of injury and did not generate detectable levels of glutathione conjugates
2014 Dec;29(12):1527-34
