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Once reaching the liver, these macrophages are inhibited by sUA, which further prevents the nuclear translocation of GLUT-4 and impedes insulin receptor substrate 2 (IRS2)/Phosphoinositide 3-kinase (PI3K)/AKT signaling
However, the addition of HCQ partially inhibit the effect of CD, indicating that reduction of DDP resistance by CAR may be associated with the enhancement of autophagy
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In the epidermis, keratinocytes secrete many cytokines to regulate melanogenesis through paracrine effects
