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Curcumin may upregulate glutathione synthesis enzymes through activation of the Nrf2 antioxidant response element pathway (Balogun et al., 2003)
MDR is defined as loss of sensitivity to antineoplastic drugs with distinct structures and different molecular targets
[DOI] [PubMed] [Google Scholar] 86
These contradictive findings revealed that the effect of curcumin on HDAC activity is variable and probably cell line specific (Meja et al., 2008)
