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Protective factors, individual, genetic or environmental, have been defined as factors that modify, ameliorate or alter a persons response to some environmental hazard that predisposes to a maladaptive outcome, and could ameliorate the detrimental effect of risk factors or even protect biologically predisposed individuals [244] from like risk factors acting across all stages of neurodevelopment

These gene clusters delineated molecular characteristics of SAAM clusters more precisely, revealing key prognostic pathways and verifying SAAM cluster stability while uncovering intrinsic molecular differences between subtypes

Observational studies: Two studies report observational data on B-12 levels in children with ADHD

If left untreated, cerebral ischemia can result in cerebral infarction, hypoxic-ischemic encephalopathy, permanent disability, or death [29,45]