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Taken together, these data show that transgenic expression of the APOE4 protein dysregulated the expression characteristics of the Pin1 , Sirt1 , and PS1 genes in different brain areas and the observed differences might contribute to the increased AD vulnerability of APOE4 mice

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By contrast, the most trialled prescription stimulant for MUD, methylphenidate, does not attenuate the rewarding properties of methamphetamine [35, 36] or reduce the severity of withdrawal symptoms [18]
