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In the cGMP-dependent pathway, NO activates guanylyl cyclase, raising cGMP levels and triggering cyclic-nucleotide-gated channels (CNGCs) that modulate Ca 2+ fluxes

10.1186/s12964-023-01302-1 183 KimK

When histamine is released from your mast cells several things may happen: Increased gastric acid secretion leading to bloating, flatulence, indigestion, constipation or diarrhea Increased heart rate Flushing Headache Itching Hives Sinus congestion In rare, more serious cases, histamine can trigger asthma attacks or even cardiac arrest

I would recommend to cancer patients to use about a half of a tablespoon per day added to meals