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Cathepsin L proteolytically processes Histone H3 during mouse embryonic stem cell differentiation

Contrary to a popular belief, astrocytes do not, through a specific pre-programmed gain of function, generate a specific toxin(s) or adopt a specific toxic phenotype proposed to be common across many diseases that may represent a universal therapeutic target

Increased GST and/or GT tumor expression, generally considered as a bad prognosis marker (associated with drug resistance and disease progression), and could potentially be used as a predictive marker, allowing doctors, after biopsy, to identify which patients will respond best to GST or GT-activated prodrugs

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