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Nat Rev Microbiol 18:392407
Although superoxide anion and hydrogen peroxide are not particularly reactive they may synergize with specific factors, eg iron, generating potent free radicals such as hydroxyl radical, which may cause direct injury through alteration of vital cellular macromolecules (DNA, protein or lipids)
The tumors in the C57BL/6 mice were unique in their early focal development of cells containing inclusions
