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There is enough primary data to say AOD-9604 does something to fat metabolism in rodents the lipolytic and fat-oxidation readouts are real and reproduced across more than one study

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Why Feeling Better Is Not the Same as Being Healed Pain relief can happen before healing is complete

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Symptoms may begin subtly with fatigue or mood changes but progress if not addressed

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Therefore, future studies are warranted to measure NE, DA, and 5-HT simultaneously and map the neurochemical landscape evoked by tesofensine (and other appetite suppressants) using either GRAB sensors with fiber photometry [65, 66] or classic in vivo microdialysis with capillary electrophoresis

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