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According to published research, preventive dietary antioxidant therapy may partially correct the redox imbalance, making it a viable method for preventing the onset of many chronic thyroidopathies ( 5.1 Thyroid dysfunctions and OxS 5.1.1 Hypothyroidism Even in its subclinical form, hypothyroidism reduces antioxidant system activity, which promotes OxS, causing oxidative damage and altered lipid metabolism in thyroid cells (46, 84)

Another protein playing a prominent role in transnitrosylation is GAPDH, a glycolytic enzyme that catalyzes conversion of glyceraldehyde 3phosphate to Dglycerate 1,3bisphosphate

1 Northeastern, Midwestern, and mid-Atlantic states experience pathogen transmission primarily by the black-legged tick, whereas the Western black-legged tick is the cause of infection on the Pacific Coast ( FIGURE 1 )

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