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Description
It also works as a substrate for sirtuins - a family of seven proteins (SIRT1-SIRT7) found in different parts of cells

While it provides significant benefits, it should be used with caution in patients with heart diseases

However, once the seal is broken, the water can no longer be considered sterile, even if it does not appear to be contaminated

Further, immune tolerance induction (ITI) protocols to mitigate ADAs are protracted (can last months to years), highly immunosuppressive (as in the case of Pompe disease) [14], and are not always effective, with little recourse available for patients who fail ITI [15]
