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Luckily, the KD can maintain gut microbiota homeostasis

5 Translational perspectives 5.1 Preclinical models and biomarker development The preclinical models and biomarker development represent the cornerstone of translational research towards incorporation of natural supplements in breast cancer therapy by adding mechanistic insights, validating efficacy, predicting therapeutic response, relevance towards patients for personalized therapy as well as on addressing their safety and dosing issues (219)

In human trials, however, the risk for muscle fiber necrosis should be monitored carefully and explored further

Even so, moving from this biochemical function to clinical outcomes is not always straightforward: the evidence can be heterogeneous and depends on dose, duration, the population studied and lifestyle variables