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Reduced Sunlight: In the winter, people often spend less time outdoors, leading to decreased exposure to sunlight

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This is chronic inflammation

MNAM, a natural inhibitor of NNMT, is generated through the enzymatic reaction catalyzed by NNMT (Swaminathan et al., 2017), the X-ray crystal structure of a ternary complex of NNMT bound with MNAM was elucidated, revealing that MNAM binds to the active site of NNMT, thereby impeding NAM binding and suppressing NNMTs enzymatic activity