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Because these neurological changes can become permanent, its important for vitamin B12 deficiency to be diagnosed and treated as early as possible
The FDA noted similar observations at the company's Wisconsin site

There is also some evidence suggesting that high doses of B12 may lead to negative health outcomes in those with diabetes or kidney disease

The addition of bacteriostatic preservatives such as benzyl alcohol became common practice during the twentieth century to allow multi-use solutions with reduced microbial contamination risk
