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By these reactions, GSH is oxidized to glutathione disulfide (GSSG)

Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain

Weeks 1 through 4: 0.5 mg once weekly Weeks 5 through 8: 1 mg once weekly Weeks 9 through 12: 2 mg once weekly Weeks 13 through 16: 4 mg once weekly Weeks 17 through 20: 6 mg once weekly Weeks 21 through 24: 8 mg once weekly Weeks 25 and beyond: 10 to 12 mg once weekly (if needed and tolerated) This protocol reaches the 8 mg therapeutic range in approximately 20 weeks

On the other hand, large animals such as nonhuman primates or pigs have gyrencephalic brains and abundant WM that make them closer to humans (369)