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Consistent with decreased fasting glucose levels and improved insulin tolerance observed under chow, and to a lesser extent under HFD conditions (Figure 1, H and I, and Figure 2, J and L), GSH depletion significantly downregulated gluconeogenic enzymes G6pc and Pck1 in chow-fed mice, with no substantial change under HFD (Figure 3, A and B)

In summary, Mdr2 / mice develop EHBD disease in addition to the well-known IHBD damage that resembles human PSC

Altogether, the major efforts in managing NF1-related neoplasms have been based on drugs targeting signaling transduction cascades such as RTK, RAS- RAFMEKERK and PI3K-AKTmTOR inhibitors