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Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells
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In vacuoles of macrophages where phagocytosed bacteria are killed, itaconate inhibits the bacterial enzyme, isocitrate lyase (ICL), a bacterial enzyme required for the glyoxylate shunt that functions during host infection by bacteria
have shown that curcumin inhibits NLRP3 inflammasome activation and interleukin-1 generation in a dextran sulfate sodium-induced colitis mouse model (Gong et al., 2018)
