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This is a safer approach because your body's natural feedback system stays intact

Achy or painful legs, especially after standing for extended periods

PLoS ONE 8:e66639 [DOI] [PMC free article] [PubMed] [Google Scholar] Kim JH, Jin S, Eo H, Oh MS, Lim Y (2023) Two faces of catechol-O-methyltransferase inhibitor on one-carbon metabolism in Parkinsons disease: a meta-analysis

[20] Pernicious anemia may be present without a person experiencing symptoms at first, over time, feeling tired and weak, lightheadedness, dizziness, headaches, rapid or irregular heartbeat, breathlessness, glossitis (a sore red tongue), poor ability to exercise, low blood pressure, cold hands and feet, pale or yellow skin, easy bruising and bleeding, low-grade fevers, tremor, cold sensitivity, chest pain, upset stomach, nausea, loss of appetite, heartburn, weight loss, diarrhea, constipation, severe joint pain, feeling abnormal sensations including tingling or numbness to the fingers and toes ( pins and needles ), and tinnitus, may occur
