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18 Besides the three ubiquitous metabolic circuitries mentioned above, acetyl-CoA also comes from organ-specific pathways

Acetyl-l-carnitine is a first-in-class epigenetic regulator of genes involved in analgesic action such as the metabotropic glutamate 2 [mGlu2] receptor gene, neurotrophic factors, and antioxidant enzymes (e.g., superoxide dismutase) (Fig
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