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The significance of group separation was tested using ANOVA-like permutation tests, with p -values corrected using the Benjamini-Hochberg procedure

There are a few mechanisms of LINE1 hypomethylation studied: [1] LINE1 hypomethylation increases the oxidative stress in bladder cancer, thereby promoting tumor progression [139] and [2] hypomethylation of the LINE1 promoter can induce an alternate splice variant of MET oncogene in bladder tumors, leading to tumor progression [140, 141]